|
KMID : 0356420110290020127
|
|
Journal of Korean Andrology
2011 Volume.29 No. 2 p.127 ~ p.133
|
|
|
The Effect of Cyanidin-3-O-β-d-glucopyranoside on the Penile Erection and Corpus Cavernosum in a Rat Model of Diabetic Erectile Dysfunction
|
|
Ha U-Syn
Koh Joon-Sung
Woo Jang-Chun
Kim Suk-Ju
Kim Su-Jin
Jang Hoon
Yoon Byung-Il
Hwang Seong-Yeon
Kim Sae-Woong
|
|
|
Abstract
|
|
|
Purpose: The aim of this study was to evaluate Cyanidin-3-O-β-d-glucopyranoside on improvement and protection for erectile function.
Materials and Methods : Sprague-Dawley rats (12wks old) were divided into three groups (n=12 in each): normal control, diabetes (DM), and diabetes with Cyanidin-3-O-β-d-glucopyranoside (C3G) concentration materials treatment (DM＋C3G). DM and DM＋C3G group received a single injection of streptozotocin (50 mg/kg), and 4 wk after induction of diabetes, DM＋C3G group were treated with daily C3G (10 mg/kg) dissolved in water for 8 wk. After 12 wk of streptozotocin injections, rats in each group underwent intracavernosal pressure measurement (ICP) and then the corporal tissues were sampled.
Results: DM group showed markedly lower erectile parameters than those in the control group, whereas rats in the DM＋C3G group showed improved erectile function by minimizing corporal apoptosis.
Conclusions: The current study is the first to suggest that Cyanidin-3-O-β-d-glucopyranoside may have a potency to improve and protect erectile function in a rat model of diabetic erectile dysfunction.
|
|
|
KEYWORD
|
|
|
Cyanidin-3-O-β-d-glucopyranoside, Diabetes Mellitus, Erectile dysfunction
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|